Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bace1tm1Nn
Name:	beta-site APP cleaving enzyme 1; targeted mutation 1, Nobuyuki Nukina
MGI ID:	MGI:3588406
Gene:	Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance:	Bace1tm1Nn page

Germline Transmission:	Earliest citation of germline transmission: J:100272
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 1 and introduced a premature translation stop codon into the open reading frame. Successful knock down was confirmed by Northern and Western blot analyses. (J:100272)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:	27 strains or lines available

Original:	J:100272 Wong HK, et al., beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem. 2005 Jun 17;280(24):23009-17
All:	1 reference(s)