Lmnatm1Lgf
Targeted Allele Detail
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Symbol: |
Lmnatm1Lgf |
Name: |
lamin A; targeted mutation 1, Loren G Fong |
MGI ID: |
MGI:3587791 |
Synonyms: |
LmnaHG |
Gene: |
Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
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Alliance: |
Lmnatm1Lgf page
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Lmnatm1Lgf/Lmnatm1Lgf mice are small and have poorly mineralized bone
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:100220
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Introns 10 and 11 and the last 150 nucleotides of exon 11 were deleted, thereby abolishing production of lamin C and producing a mutated prelamin A that precludes wild-type Lmna synthesis. A loxP flanked neo was inserted downstream of exon 12. Western blot of mutant MEFs demonstrated the expression of large amounts of mutant prelamin A.
(J:100220)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lmna Mutation: |
82 strains or lines available
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Original: |
J:100220 Yang SH, et al., Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10291-6 |
All: |
8 reference(s) |
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