Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myo1atm1Mtys
Name:	myosin IA; targeted mutation 1, Matthew J Tyska
MGI ID:	MGI:3587749
Gene:	Myo1a  Location: Chr10:127541039-127556809 bp, + strand  Genetic Position: Chr10, 74.62 cM
Alliance:	Myo1atm1Mtys page

Germline Transmission:	Earliest citation of germline transmission: J:100193
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S1/SvImJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo/ura3 cassette replaced the first three exons. Absence of protein in mutants was confirmed by immunoblot of small intestines. Immunostaining of mutant duodenal sections with an antibody directed against the TH1 domain showed the expected lack of signal in mutants. (J:100193)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myo1a Mutation:	62 strains or lines available

Original:	J:100193 Tyska MJ, et al., Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell. 2005 May;16(5):2443-57
All:	5 reference(s)