Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klbtm1Yin
Name:	klotho beta; targeted mutation 1, Yo-ichi Nabeshima
MGI ID:	MGI:3587748
Synonyms:	beta-kl-, Betaklotho-
Gene:	Klb  Location: Chr5:65505657-65541350 bp, + strand  Genetic Position: Chr5, 33.64 cM
Alliance:	Klbtm1Yin page

Germline Transmission:	Earliest citation of germline transmission: J:100209
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of the putative exon 1 containing the first ATG was deleted upon the insertion of an EGFP with a loxP-flanked PGK-neo in reverse orientation. Northern blot and RT-PCR confirmed lack of transcript in mutant liver samples. Absence of protein was demonstrated by Western blot of mutant liver, white adipose tissue and kidney. (J:100209)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Klb Mutation:	58 strains or lines available

Original:	J:100209 Ito S, et al., Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest. 2005 Aug 1;115(8):2202-2208
All:	8 reference(s)