Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp1r12atm1Mito
Name:	protein phosphatase 1, regulatory subunit 12A; targeted mutation 1, Masaaki Ito
MGI ID:	MGI:3586994
Synonyms:	MYPT1-
Gene:	Ppp1r12a  Location: Chr10:107997913-108115846 bp, + strand  Genetic Position: Chr10, 56.33 cM, cytoband C
Alliance:	Ppp1r12atm1Mito page

Germline Transmission:	Earliest citation of germline transmission: J:100069
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A neomycin resistance gene was inserted into exon 1, allowing only the first 12 amino acids to be transcribed. The N-terminal fragment was not detected in mutants by either Northern or Western blot analyses. (J:100069)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp1r12a Mutation:	62 strains or lines available

Original:	J:100069 Okamoto R, et al., The targeted disruption of the MYPT1 gene results in embryonic lethality. Transgenic Res. 2005 Jun;14(3):337-40
All:	1 reference(s)