Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Ube2d2atm1Ssw
Name:	ubiquitin-conjugating enzyme E2D 2A; targeted mutation 1, Simon S Wing
MGI ID:	MGI:3586923
Synonyms:	UBC4-
Gene:	Ube2d2a  Location: Chr18:35904612-35940225 bp, + strand  Genetic Position: Chr18, 19.24 cM
Alliance:	Ube2d2atm1Ssw page

Germline Transmission:	Earliest citation of germline transmission: J:100020
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding amino acid residues 2 to 126 were replaced with a neomycin resistance cassette, removing 124 of 147 residues, including all of the elements making up the active site. Northern blot confirmed absence of wild-type transcript in mutant testis, but showed the presence of a longer transcript resulting from transcription through the larger neomycin resistance cassette. Western blot demonstrated absence of protein in mutant testis. (J:100020)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ube2d2a Mutation:	13 strains or lines available

Original:	J:100020 Bedard N, et al., Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Mol Cell Biol. 2005 Aug;25(15):6346-54
All:	1 reference(s)