Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fem1btm1Jfma
Name:	fem 1 homolog b; targeted mutation 1, Joseph F Maher
MGI ID:	MGI:3586916
Synonyms:	Fem1b-
Gene:	Fem1b  Location: Chr9:62699106-62718930 bp, - strand  Genetic Position: Chr9, 33.87 cM
Alliance:	Fem1btm1Jfma page

Germline Transmission:	Earliest citation of germline transmission: J:100017
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo cassette replaced the first exon, which contains the translation initiation codon and the first two ankyrin repeats. Northern blot from mutant testis confirmed absence of transcript and Western blot of mutant brain showed absence of protein. (J:100017)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fem1b Mutation:	28 strains or lines available

Original:	J:100017 Lu D, et al., Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the fem1b gene. Mol Cell Biol. 2005 Aug;25(15):6570-7
All:	1 reference(s)