Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Upp1tm1Gp
Name:	uridine phosphorylase 1; targeted mutation 1, Giuseppe Pizzorno
MGI ID:	MGI:3586525
Synonyms:	UPase-
Gene:	Upp1  Location: Chr11:9068103-9086170 bp, + strand  Genetic Position: Chr11, 6.13 cM, cytoband A1-2
Alliance:	Upp1tm1Gp page

Germline Transmission:	Earliest citation of germline transmission: J:99912
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 3, all of exon 4 and most of exon 5 were replaced with a neomycin resistance gene. This deletion resulted in the loss of 92 amino acids followed by a frame shift. RT-PCR of mutant liver, gut, lung and kidney confirmed absence of transcript. (J:100071)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Upp1tm1Gp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Upp1 Mutation:	66 strains or lines available

Original:	J:99912 Cao D, et al., Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J Biol Chem. 2005 Jun 3;280(22):21169-75
All:	10 reference(s)