Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fzd9tm1Sjp
Name:	frizzled class receptor 9; targeted mutation 1, Samuel J Pleasure
MGI ID:	MGI:3586504
Gene:	Fzd9  Location: Chr5:135277792-135279901 bp, - strand  Genetic Position: Chr5, 75.08 cM
Alliance:	Fzd9tm1Sjp page

Germline Transmission:	Earliest citation of germline transmission: J:99893
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire 1.8 kb coding exon was replaced by an IRES-lacZ-loxP-neo-loxP cassette. RT-PCR of mutant brain confirmed recomibination and expression of lacZ. X-gal staining, however, did not detect lacZ. Immunohistochemistry demonstrated lack of endogenous protein in mutants. (J:99893)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd9 Mutation:	36 strains or lines available

Original:	J:99893 Zhao C, et al., Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development. 2005 Jun;132(12):2917-27
All:	2 reference(s)