Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ilf3tm1Pnk
Name:	interleukin enhancer binding factor 3; targeted mutation 1, Peter N Kao
MGI ID:	MGI:3586304
Synonyms:	NF90-
Gene:	Ilf3  Location: Chr9:21279167-21316657 bp, + strand  Genetic Position: Chr9, 7.78 cM, cytoband A4-A5
Alliance:	Ilf3tm1Pnk page

Germline Transmission:	Earliest citation of germline transmission: J:99935
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced exons 2-4, resulting in the deletion of the ATG codon and the introduction of a frameshift that disrupted the ORF. Northern blot of mutants confirmed recombination, and Western blot demonstrated complete lack of protein in mutants. (J:99935)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ilf3 Mutation:	78 strains or lines available

Original:	J:99935 Shi L, et al., NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs. J Biol Chem. 2005 May 13;280(19):18981-9
All:	3 reference(s)