Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Polgtm1.2Lrsn
Name:	polymerase (DNA directed), gamma; targeted mutation 1.2, Nils-Goran Larsson
MGI ID:	MGI:3584444
Synonyms:	PolgA-
Gene:	Polg  Location: Chr7:79095979-79116110 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Alliance:	Polgtm1.2Lrsn page

Germline Transmission:	Earliest citation of germline transmission: J:99794
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Mice carrying the floxed allele Polgtm1Lrsn were crossed with mice expressing cre ubiquitously, causing the removal of exon 3. Deletion of exon 3 results in a frameshift mutation leading to a stop codon early in exon 4 and the loss of nearly all active domains of the locus. (J:99794)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polg Mutation:	57 strains or lines available

Original:	J:99794 Hance N, et al., Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet. 2005 Jul 1;14(13):1775-83
All:	2 reference(s)