Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pak3tm1Zpj
Name:	p21 (RAC1) activated kinase 3; targeted mutation 1, Zhengping Jia
MGI ID:	MGI:3584167
Synonyms:	PAK3-
Gene:	Pak3  Location: ChrX:142301587-142580792 bp, + strand  Genetic Position: ChrX, 64.5 cM
Alliance:	Pak3tm1Zpj page

Germline Transmission:	Earliest citation of germline transmission: J:99811
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector containing a pgk-neo cassette was designed to eliminate the region encoding the entire kinase domain. Protein was undetected in Western blot analyses of mutant brain lysates. (J:99811)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pak3 Mutation:	24 strains or lines available

Original:	J:99811 Meng J, et al., Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50
All:	4 reference(s)