Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gria2tm1Rlh
Name:	glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, Richard L Huganir
MGI ID:	MGI:3584143
Synonyms:	GluR2delta7
Gene:	Gria2  Location: Chr3:80588757-80710142 bp, - strand  Genetic Position: Chr3, 35.5 cM
Alliance:	Gria2tm1Rlh page

Germline Transmission:	Earliest citation of germline transmission: J:99813
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An artificial stop codon was inserted upstream of the exon encoding transmembrane 4 and the C terminus region. A floxed neo included in the construct was deleted via cre-mediated recombination. Western blot failed to detect protein using the antibody designed to recognize the last 7 amino acids of the C terminus. (J:99813)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria2 Mutation:	75 strains or lines available

Original:	J:99813 Gardner SM, et al., Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron. 2005 Mar 24;45(6):903-15
All:	9 reference(s)