Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Myctm1Lbox Name: myelocytomatosis oncogene; targeted mutation 1, Linda M Boxer MGI ID: MGI:3583919 Synonyms: IgH-3'E-myc Gene: Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3 Alliance: Myctm1Lbox page

Histopathological analysis of lymphomas in Myctm1Lbox/Myctm1Lbox and Myctm1Lbox/Myc+ mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:97900
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutation:    Insertion   Mutation details: The IgH 3' enhancers SH1234 were inserted upstream of the locus. RT-PCR of mutants demonstrated elevated transcript levels in spleenic B-lymphocytes, but normal levels in brain, liver, kidney, lung and thymus. (J:97900)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:	42 strains or lines available

Original:	J:97900 Wang J, et al., Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells. J Biol Chem. 2005 Apr 1;280(13):12766-73
All:	2 reference(s)