Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ipmktm1Yrk Name: inositol polyphosphate multikinase; targeted mutation 1, John D York MGI ID: MGI:3583918 Gene: Ipmk  Location: Chr10:71183574-71221715 bp, + strand  Genetic Position: Chr10, 36.89 cM, cytoband B5.2 Alliance: Ipmktm1Yrk page

Morphological analysis of Ipmktm1Yrk/Ipmktm1Yrk embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:99723
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4, encoding the critical kinase motif DVKIG and residues critical to protein folding, was replaced with a neomycin resistance cassette via homologous recombination. In situ hybridization experiments indicated that no detectable transcript was expressed from this allele. (J:99723)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ipmk Mutation:	30 strains or lines available

Original:	J:99723 Frederick JP, et al., An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8454-9
All:	2 reference(s)