Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ms4a2tm1Chr
Name:	membrane-spanning 4-domains, subfamily A, member 2; targeted mutation 1, Chisei Ra
MGI ID:	MGI:3583705
Synonyms:	FcRB(-), FcRbeta(-)
Gene:	Ms4a2  Location: Chr19:11592887-11601083 bp, - strand  Genetic Position: Chr19, 8.46 cM
Alliance:	Ms4a2tm1Chr page

Germline Transmission:	Earliest citation of germline transmission: J:53106
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 1, which includes the translation initiation codon and splice donor site, via homologous recombination. Northern blot and western blot analyses failed to detect signal in homozygotes indicating a null allele. (J:53106)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ms4a2 Mutation:	12 strains or lines available

Original:	J:53106 Hiraoka S, et al., Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. Int Immunol. 1999 Feb;11(2):199-207
All:	7 reference(s)