Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rec8tm1Mjm
Name:	REC8 meiotic recombination protein; targeted mutation 1, Michael J McKay
MGI ID:	MGI:3583574
Synonyms:	Rec8-
Gene:	Rec8  Location: Chr14:55855494-55862852 bp, + strand  Genetic Position: Chr14, 28.19 cM
Alliance:	Rec8tm1Mjm page

Germline Transmission:	Earliest citation of germline transmission: J:99402
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace 19 coding exons with a loxP-flanked cassette containing GFP and a neomycin resistance cassette. Testes from mutants were demonstrated to lack mRNA by Northern blot analysis. (J:99402)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rec8 Mutation:	25 strains or lines available

Original:	J:99402 Xu H, et al., Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev Cell. 2005 Jun;8(6):949-61
All:	4 reference(s)