Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighmtm1Sls
Name:	immunoglobulin heavy constant mu; targeted mutation 1, Erik Selsing
MGI ID:	MGI:3582575
Synonyms:	Smu
Gene:	Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance:	Ighmtm1Sls page

Germline Transmission:	Earliest citation of germline transmission: J:99465
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The entire tandem repeat region was replaced by a Neo/loxP cassette which was later removed by crossing to a Cre recombinase transgenic strain, leaving one loxP site. The enhancer, matrix attachment regions and the I exon were left intact. (J:99465)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:	55 strains or lines available

Original:	J:99465 Luby TM, et al., The mu switch region tandem repeats are important, but not required, for antibody class switch recombination. J Exp Med. 2001 Jan 15;193(2):159-68
All:	6 reference(s)