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Pou4f2tm1Rsd
Targeted Allele Detail
Summary
Symbol: Pou4f2tm1Rsd
Name: POU domain, class 4, transcription factor 2; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:3582493
Synonyms: Brn3.2-
Gene: Pou4f2  Location: Chr8:79159639-79163274 bp, - strand  Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
Alliance: Pou4f2tm1Rsd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33502
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA neomycin selection cassette replaced a 2.7 kb genomic fragment containing the entire coding sequence of the gene. Immunohistochemical analysis on sections of newborn dorsal root ganglia of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:33502)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pou4f2 Mutation:  7 strains or lines available
References
Original:  J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory