Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Eif2ak4tm1.2Dron
Name:	eukaryotic translation initiation factor 2 alpha kinase 4; targeted mutation 1.2, David Ron
MGI ID:	MGI:3582154
Synonyms:	Eif2ak4tm1Munn, Eif2ak4tm1Nso, GCN2-KO, GCN2.KO4, GCN2.KO4ex, GNC2-
Gene:	Eif2ak4  Location: Chr2:118219099-118305715 bp, + strand  Genetic Position: Chr2, 59.4 cM, cytoband E5
Alliance:	Eif2ak4tm1.2Dron page

Germline Transmission:	Earliest citation of germline transmission: J:129841
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 12 was deleted via Cre-mediated excision, removing sequence encoding the essential lysine 618, required for kinase activity. (J:99090)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

104036 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Eif2ak4 Mutation:	88 strains or lines available

Original:	J:129841 Maurin AC, et al., The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab. 2005 Apr;1(4):273-7
All:	64 reference(s)