Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrm4tm1Minm
Name:	cholinergic receptor, muscarinic 4; targeted mutation 1, Minoru Matsui
MGI ID:	MGI:3581713
Gene:	Chrm4  Location: Chr2:91757594-91759033 bp, + strand  Genetic Position: Chr2, 50.63 cM
Alliance:	Chrm4tm1Minm page

Germline Transmission:	Earliest citation of germline transmission: J:99248
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo-bpA cassette in the reverse orientation replaced the coding region via homologous recombination. Northern blot analysis confirmed the absence of mRNA in the brain. (J:99248)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm4 Mutation:	33 strains or lines available

Original:	J:99248 Karasawa H, et al., Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4. Eur J Pharmacol. 2003 May 2;468(1):15-9
All:	6 reference(s)