Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fntbtm1.1Bbd
Name:	farnesyltransferase, CAAX box, beta; targeted mutation 1.1, Mariano Barbacid
MGI ID:	MGI:3581448
Synonyms:	FT-
Gene:	Fntb  Location: Chr12:76884014-76968188 bp, + strand  Genetic Position: Chr12, 33.73 cM
Alliance:	Fntbtm1.1Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:98944
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre expression mediated the excision of the exon 3 in Fntbtm1Bbd. The predominant transcript produced by the mutant allele does not contain a frameshift but rather encodes a protein with a short in-frame deletion. (J:98944, J:149075)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fntb Mutation:	207 strains or lines available

Original:	J:98944 Mijimolle N, et al., Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 2005 Apr;7(4):313-24
All:	2 reference(s)