Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cox4i2tm1Hutt
Name:	cytochrome c oxidase subunit 4I2; targeted mutation 1, Maik Huttemann
MGI ID:	MGI:3580677
Gene:	Cox4i2  Location: Chr2:152596093-152606957 bp, + strand  Genetic Position: Chr2, 75.41 cM, cytoband H2
Alliance:	Cox4i2tm1Hutt page

Germline Transmission:	Earliest citation of germline transmission: J:187640
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of transcripts in homozygous mice. Western blot analysis confirmed the absence of protein expression in lungs from homozygous mice. (J:187640)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cox4i2 Mutation:	13 strains or lines available

Original:	J:187640 Huttemann M, et al., Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB J. 2012 Sep;26(9):3916-30
All:	5 reference(s)