Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Celsr3tm1Agof
Name:	cadherin, EGF LAG seven-pass G-type receptor 3; targeted mutation 1, Andre M Goffinet
MGI ID:	MGI:3578665
Gene:	Celsr3  Location: Chr9:108703519-108730168 bp, + strand  Genetic Position: Chr9, 59.63 cM
Alliance:	Celsr3tm1Agof page

Germline Transmission:	Earliest citation of germline transmission: J:98367
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was designed to delete exons 19-27. Transcript levels were two- to fourfold lower in mutants than in wild-type animals. RT-PCR confirmed deletion of exons 19-27. A cryptic splice acceptor site in modified intron 27 resulted in an 87-nt 5' extension of exon 28. The resulting protein lacks the GPS, 7TM and C-terminal cytoplasmic sequences. (J:98367)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Celsr3 Mutation:	122 strains or lines available

Original:	J:98367 Tissir F, et al., Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci. 2005 Apr;8(4):451-7
All:	22 reference(s)