Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rbbp8tm1Whl
Name:	retinoblastoma binding protein 8, endonuclease; targeted mutation 1, Wen-Hwa Lee
MGI ID:	MGI:3577029
Synonyms:	Ctip-
Gene:	Rbbp8  Location: Chr18:11766333-11876264 bp, + strand  Genetic Position: Chr18, 5.85 cM
Alliance:	Rbbp8tm1Whl page

Germline Transmission:	Earliest citation of germline transmission: J:97648
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-NeopA was inserted into exon 5 at the position equivalent to amino acid residue 109 in the human protein. (J:97648)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Rbbp8tm1Whl

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbbp8 Mutation:	51 strains or lines available

Original:	J:97648 Chen PL, et al., Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G1 Restraint and to Tumorigenesis by Haploid Insufficiency. Mol Cell Biol. 2005 May;25(9):3535-42
All:	5 reference(s)