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Ppiftm1Tsu
Targeted Allele Detail
Summary
Symbol: Ppiftm1Tsu
Name: peptidylprolyl isomerase F (cyclophilin F); targeted mutation 1, Yoshihide Tsujimoto
MGI ID: MGI:3577023
Gene: Ppif  Location: Chr14:25694578-25700892 bp, + strand  Genetic Position: Chr14, 15.06 cM
Alliance: Ppiftm1Tsu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97673
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ/MCI-neo cassette replaced exons 1-5. Western blot of lysates from various tissues confirmed absence of protein. (J:97673)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppif Mutation:  18 strains or lines available
References
Original:  J:97673 Nakagawa T, et al., Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 2005 Mar 31;434(7033):652-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory