Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smurf1tm1Yez
Name:	SMAD specific E3 ubiquitin protein ligase 1; targeted mutation 1, Ying E Zhang
MGI ID:	MGI:3576775
Synonyms:	Smurf-
Gene:	Smurf1  Location: Chr5:144813305-144902657 bp, - strand  Genetic Position: Chr5, 84.83 cM, cytoband G2
Alliance:	Smurf1tm1Yez page

Germline Transmission:	Earliest citation of germline transmission: J:97303
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace three exons with a neomycin resistance gene, thereby generating a truncated protein product lacking two highly concerved WW domains and the HECT ubiquitin ligase domain. (J:97303)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smurf1 Mutation:	52 strains or lines available

Original:	J:97303 Yamashita M, et al., Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell. 2005 Apr 8;121(1):101-13
All:	9 reference(s)