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Umodtm1Kuma
Targeted Allele Detail
Summary
Symbol: Umodtm1Kuma
Name: uromodulin; targeted mutation 1, Satish Kumar
MGI ID: MGI:3574985
Synonyms: THP-
Gene: Umod  Location: Chr7:119061931-119078485 bp, - strand  Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
Alliance: Umodtm1Kuma page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97228
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of a neo interrupted the coding sequence in exon 2. Northern and Western blot as well as immunocytochemistry confirmed absence of transcript and protein in mutant mice. (J:97228)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Umod Mutation:  4 strains or lines available
References
Original:  J:97228 Bates JM, et al., Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int. 2004 Mar;65(3):791-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory