Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc18a2tm1Edw
Name:	solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1, Robert H Edwards
MGI ID:	MGI:3574768
Synonyms:	VMAT2-, VMAT2KO
Gene:	Slc18a2  Location: Chr19:59249328-59284444 bp, + strand  Genetic Position: Chr19, 54.64 cM
Alliance:	Slc18a2tm1Edw page

Germline Transmission:	Earliest citation of germline transmission: J:45183
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first and second protein coding exons were replaced with a neomycin resistance gene. Western blot analysis and quantitation of protein by tetrabenzine binding of mutant membrane vesicles confirmed absence of protein. (J:45183)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc18a2 Mutation:	29 strains or lines available

Original:	J:45183 Fon EA, et al., Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron. 1997 Dec;19(6):1271-83
All:	5 reference(s)