Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cfl1tm1.2Wit
Name:	cofilin 1, non-muscle; targeted mutation 1.2, Walter Witke
MGI ID:	MGI:3574399
Synonyms:	deltacof, n-cof-
Gene:	Cfl1  Location: Chr19:5540483-5544059 bp, + strand  Genetic Position: Chr19, 4.34 cM
Alliance:	Cfl1tm1.2Wit page

Germline Transmission:	Earliest citation of germline transmission: J:96452
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cfl1tm1Wit mice were crossed to Cre-deleter mice to delete exon 2 and the neo cassette. The deletion created a frame shift and immediate translational stop. Western blot confirmed absence of protein in mutant embryo lysates. (J:96452)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfl1 Mutation:	25 strains or lines available

Original:	J:96452 Gurniak CB, et al., The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005 Feb 1;278(1):231-41
All:	6 reference(s)