Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hey2tm1Kkb
Name:	hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Hiroki Kokubo
MGI ID:	MGI:3574394
Synonyms:	hesr2-
Gene:	Hey2  Location: Chr10:30708355-30718779 bp, - strand  Genetic Position: Chr10, 17.19 cM, cytoband A4
Alliance:	Hey2tm1Kkb page

Germline Transmission:	Earliest citation of germline transmission: J:97120
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting construct was designed to delete the entire coding region by replacing it with a loxP neo cassette subsequently removed via cre mediated excision. (J:97120)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hey2 Mutation:	30 strains or lines available

Original:	J:97120 Kokubo H, et al., Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 3;95(5):540-7
All:	6 reference(s)