Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itga10tm1Ref
Name:	integrin, alpha 10; targeted mutation 1, Reinhard Fassler
MGI ID:	MGI:3574026
Gene:	Itga10  Location: Chr3:96552900-96571835 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Alliance:	Itga10tm1Ref page

Germline Transmission:	Earliest citation of germline transmission: J:96524
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An EGFP and loxP flanked neo were inserted to replace exon 1. RT-PCR of hearts from mutant mice demonstrated the lack of transcript. Loss of protein was further confirmed by Western blot of chondrocyte lysates and immunostaining of newborn knee cartilage. (J:96524)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga10 Mutation:	74 strains or lines available

Original:	J:96524 Bengtsson T, et al., Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci. 2005 Mar 1;118(Pt 5):929-36
All:	1 reference(s)