Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gzmbtm2.1Ley
Name:	granzyme B; targeted mutation 2.1, Timothy J Ley
MGI ID:	MGI:3574017
Synonyms:	GzmB-/deltaPGK-neo
Gene:	Gzmb  Location: Chr14:56496295-56499717 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband D3
Alliance:	Gzmbtm2.1Ley page

Germline Transmission:	Earliest citation of germline transmission: J:96538
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The PGK-neo was removed from Gzmbtm1Ley via transient expression of cre recombinase. This allele is missing a 350bp AvrII fragment starting within the 5' untranslated region (22 bp upstream from the initiation codon), extending through exon 1 and part of intron 1. (J:96538)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gzmb Mutation:	26 strains or lines available

Original:	J:96538 Revell PA, et al., Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol. 2005 Feb 15;174(4):2124-31
All:	9 reference(s)