Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cr2tm1Tft
Name:	complement receptor 2; targeted mutation 1, Thomas F Tedder
MGI ID:	MGI:3531094
Synonyms:	CD21/35-
Gene:	Cr2  Location: Chr1:194819119-194859024 bp, - strand  Genetic Position: Chr1, 98.44 cM
Alliance:	Cr2tm1Tft page

Germline Transmission:	Earliest citation of germline transmission: J:95979
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 5' promoter region and exon encoding the transcription initiation and signal sequence of the gene were replaced by a neo cassette. Western blot analysis and binding assays failed to detect any protein or binding activity in mutant B cells and lymphocytes, respectively (J:95979)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cr2 Mutation:	84 strains or lines available

Original:	J:95979 Haas KM, et al., Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity. 2002 Dec;17(6):713-23
All:	9 reference(s)