Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rtn4rtm1Matl
Name:	reticulon 4 receptor; targeted mutation 1, Marc Tessier-Lavigne
MGI ID:	MGI:3530480
Synonyms:	NgR-, NgR1-, Ngr1taulacZ
Gene:	Rtn4r  Location: Chr16:17945506-17970272 bp, + strand  Genetic Position: Chr16, 11.23 cM, cytoband B1
Alliance:	Rtn4rtm1Matl page

Germline Transmission:	Earliest citation of germline transmission: J:96121
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-TAU-LacZ and a floxed neo replaced most of the coding sequence in exon 2 by homologous recombination. Any transcript translated would be only the first 19 amino acids. Northern blot of mutant brain tissues demonstrated the absence of a wild-type transcript and confirmed the creation of a null allele. (J:96121)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rtn4r Mutation:	24 strains or lines available

Original:	J:96121 Zheng B, et al., Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1205-10
All:	15 reference(s)