Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkd1tm1Tko
Name:	naked cuticle 1; targeted mutation 1, Makoto M Taketo
MGI ID:	MGI:3530367
Synonyms:	Nkd1-
Gene:	Nkd1  Location: Chr8:89247982-89321512 bp, + strand  Genetic Position: Chr8, 43.36 cM, cytoband C4
Alliance:	Nkd1tm1Tko page

Germline Transmission:	Earliest citation of germline transmission: J:95901
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 5 and 6, containing 60 amino acids comprising most of the EF-hand-containing oxygen donation and ion-binding domains, were replaced with a PGK-neo. Exons 4 and 7 were spliced together and resulted in a mutant transcript and protein lacking exons 5 and 6, as shown by Northern blot analysis, RT-PCR and Western blot. (J:95901)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkd1 Mutation:	17 strains or lines available

Original:	J:95901 Li Q, et al., A targeted mutation of Nkd1 impairs mouse spermatogenesis. J Biol Chem. 2005 Jan 28;280(4):2831-9
All:	1 reference(s)