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Klf10tm1Sub
Targeted Allele Detail
Summary
Symbol: Klf10tm1Sub
Name: Kruppel-like transcription factor 10; targeted mutation 1, Malayannan Subramaniam
MGI ID: MGI:3530069
Synonyms: KLF10-, TIEG-
Gene: Klf10  Location: Chr15:38291707-38300950 bp, - strand  Genetic Position: Chr15, 15.15 cM
Alliance: Klf10tm1Sub page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95992
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2, including transcription and translation start sites and the first 114 amino acids, were replaced with a neo cassette with a polyA signal. Northern blot of mutants confirmed absence of transcript and immunoprecipitation demonstrated the lack of protein in mutants. (J:95992)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Klf10tm1Sub
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf10 Mutation:  25 strains or lines available
References
Original:  J:95992 Subramaniam M, et al., TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol. 2005 Feb;25(3):1191-9
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory