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Mchr1tm1Lex
Targeted Allele Detail
Summary
Symbol: Mchr1tm1Lex
Name: melanin-concentrating hormone receptor 1; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528891
Synonyms: Mch1r-
Gene: Mchr1  Location: Chr15:81119700-81123165 bp, + strand  Genetic Position: Chr15, 38.02 cM
Alliance: Mchr1tm1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136869
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsBoth exons 1 and 2 from the gene coding for entire coding sequece of the gene were replaced with a neo cassette. The absence of expression was confirmed by RT-PCR on RNA from whole brains of homozygous mice. This is a null allele. (J:136869)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mchr1 Mutation:  24 strains or lines available
References
Original:  J:136869 Roy M, et al., Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. Neuropsychopharmacology. 2006 Jan;31(1):112-20
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory