Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hrh4tm1Lex
Name:	histamine receptor H4; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3528886
Synonyms:	H4R-, Hrh4tm1Thr
Gene:	Hrh4  Location: Chr18:13140047-13155939 bp, + strand  Genetic Position: Chr18, 6.88 cM
Alliance:	Hrh4tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:132140
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 that contains the ATG translation initiation site was replaced with a neo cassette. Authors state that this is a null allele. (J:132140)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hrh4 Mutation:	26 strains or lines available

Original:	J:132140 Hofstra CL, et al., Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther. 2003 Jun;305(3):1212-21
All:	17 reference(s)