Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mchr1tm1Dgam
Name:	melanin-concentrating hormone receptor 1; targeted mutation 1, David G A Morgan
MGI ID:	MGI:3527904
Synonyms:	MCHR1-
Gene:	Mchr1  Location: Chr15:81119700-81123165 bp, + strand  Genetic Position: Chr15, 38.02 cM
Alliance:	Mchr1tm1Dgam page

Germline Transmission:	Earliest citation of germline transmission: J:95740
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo replaced the coding region of both exons. Real time PCR demonstrated that mutant brains expressed no transcript from the locus. (J:95740)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mchr1 Mutation:	24 strains or lines available

Original:	J:95740 Astrand A, et al., Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R749-58
All:	3 reference(s)