Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Matktm1Sor
Name:	megakaryocyte-associated tyrosine kinase; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:3526800
Synonyms:	Matk/CHK-
Gene:	Matk  Location: Chr10:81088769-81098819 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Alliance:	Matktm1Sor page

Germline Transmission:	Earliest citation of germline transmission: J:109203
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A DNA fragment of approximately 500 bp that includes exon 7, which encodes a peptide sequence essential for ATP binding, has been replaced by a neomycin resistance cassette. (J:109203)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Matk Mutation:	30 strains or lines available

Original:	J:109203 Lee BC, et al., Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice. Blood. 2006 Aug 1;108(3):904-7
All:	2 reference(s)