Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apex2tm1Yun
Name:	apurinic/apyrimidinic endonuclease 2; targeted mutation 1, Yusaku Nakabeppu
MGI ID:	MGI:3526443
Gene:	Apex2  Location: ChrX:149302515-149372864 bp, - strand  Genetic Position: ChrX, 68.46 cM, cytoband F2
Alliance:	Apex2tm1Yun page

Germline Transmission:	Earliest citation of germline transmission: J:95267
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace the 3' end of intron 5 and the 5' end of exon 6 with a neo in the opposite orientation. Northern blot showed that mutant ES cells did not contain wild-type transcript. (J:82005)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apex2 Mutation:	4 strains or lines available

Original:	J:95267 Ide Y, et al., Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood. 2004 Dec 15;104(13):4097-103
All:	8 reference(s)