Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcna2tm1Tem
Name:	potassium voltage-gated channel, shaker-related subfamily, member 2; targeted mutation 1, Bruce L Tempel
MGI ID:	MGI:3526017
Gene:	Kcna2  Location: Chr3:107008462-107022321 bp, + strand  Genetic Position: Chr3, 46.61 cM
Alliance:	Kcna2tm1Tem page

Germline Transmission:	Earliest citation of germline transmission: J:131735
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced the entire open reading frame. mRNAQ cannot be found by quantitative PCR and protein product cannot be identified by Western blot in extracts from homozygous mutant mice. (J:131735)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcna2 Mutation:	40 strains or lines available

Original:	J:131735 Brew HM, et al., Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J Neurophysiol. 2007 Sep;98(3):1501-25
All:	5 reference(s)