Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aph1btm1Bdes
Name:	aph1 homolog B, gamma secretase subunit; targeted mutation 1, Bart De Strooper
MGI ID:	MGI:3522628
Synonyms:	Aph1b-
Gene:	Aph1b  Location: Chr9:66682484-66702772 bp, - strand  Genetic Position: Chr9, 36.12 cM, cytoband D
Alliance:	Aph1btm1Bdes page

Germline Transmission:	Earliest citation of germline transmission: J:96106
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a modified human placental alkaline phosphatase reporter sequence, polyA signal at the ATG in exon 1. RT-PCR and Western blot of mutant MEFs demonstrated the expression of mRNA or protein, respectively. (J:96106)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aph1b Mutation:	19 strains or lines available

Original:	J:96106 Serneels L, et al., Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24
All:	6 reference(s)