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Park7tm1Cai
Targeted Allele Detail
Summary
Symbol: Park7tm1Cai
Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Hubaibin Cai
MGI ID: MGI:3522482
Gene: Park7  Location: Chr4:150981590-150994378 bp, - strand  Genetic Position: Chr4, 81.52 cM, cytoband E1
Alliance: Park7tm1Cai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141628
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first coding exon was replaced with a selection marker flanked with loxp sites. QPCR and Western blot analysis confirmed the absence of gene products. (J:141628)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Park7 Mutation:  53 strains or lines available
References
Original:  J:141628 Chandran JS, et al., Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis. 2008 Mar;29(3):505-14
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory