Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnn2tm1.1Jpad
Name:	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; targeted mutation 1.1, John P Adelman
MGI ID:	MGI:3522425
Synonyms:	SK2delta
Gene:	Kcnn2  Location: Chr18:45401927-45818950 bp, + strand  Genetic Position: Chr18, 24.34 cM, cytoband C
Alliance:	Kcnn2tm1.1Jpad page

Germline Transmission:	Earliest citation of germline transmission: J:94941
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted 300 nucleotides 5' of the initiation methionine codon in exon 1 and a floxed neomycin resistance gene as well as an EGFP gene were inserted in intron 2. Crossing to cre-deleter mice led to the excision of the the coding portion of exon 1 and exon 2 as well as the neo resistance gene. RT-PCR and Western blot analysis confirmed the absence of transcription and translation. The EGFP insert was non functional. (J:94941)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnn2 Mutation:	43 strains or lines available

Original:	J:94941 Bond CT, et al., Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci. 2004 Jun 9;24(23):5301-6
All:	16 reference(s)