Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Top2btm2.1Jcw
Name:	topoisomerase (DNA) II beta; targeted mutation 2.1, James C Wang
MGI ID:	MGI:3521923
Synonyms:	top2betadelta2
Gene:	Top2b  Location: Chr14:6038976-6104585 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance:	Top2btm2.1Jcw page

Germline Transmission:	Earliest citation of germline transmission: J:94879
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed region was excised from Top2btm2Jcw by crossing to mice carrying Tg(PRM-Cre)58Og. (J:94879)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	59 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Top2b Mutation:	91 strains or lines available

Original:	J:94879 Lyu YL, et al., Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7123-8
All:	7 reference(s)