Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cst8tm1Itl
Name:	cystatin 8 (cystatin-related epididymal spermatogenic); targeted mutation 1, Ingenious Targeting Laboratory
MGI ID:	MGI:3521755
Synonyms:	CRES-, Cst8-, Cst8tm1Cnw
Gene:	Cst8  Location: Chr2:148640759-148647516 bp, + strand  Genetic Position: Chr2, 73.56 cM
Alliance:	Cst8tm1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:126945
Parent Cell Line:	iTL1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Not Specified   Mutation details: A neo cassette replaced 4 kb of the genomic fragment, including part of exon 1 (5' untranslated region [UTR]) and all of exon 2. Western blot analysis confirmed the absence of protein expression in tissue lysates from the testis and epididymis of homozygous mutant mice. (J:168157)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cst8 Mutation:	8 strains or lines available

Original:	J:126945 von Horsten HH, et al., Oligomerization and transglutaminase cross-linking of the cystatin CRES in the mouse epididymal lumen: potential mechanism of extracellular quality control. J Biol Chem. 2007 Nov 9;282(45):32912-23
All:	4 reference(s)