About   Help   FAQ
Lrrk2tm1Tmd
Targeted Allele Detail
Summary
Symbol: Lrrk2tm1Tmd
Name: leucine-rich repeat kinase 2; targeted mutation 1, Ted Dawson
MGI ID: MGI:3514169
Gene: Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance: Lrrk2tm1Tmd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143967
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a floxed neomycin resistance cassette partially deletes exon 39 and completely deletes exon 40. No protein expression was detected in homozygous brain lysates as determined by immunoblot analysis. (J:143967)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:  156 strains or lines available
References
Original:  J:143967 Biskup S, et al., Dynamic and redundant regulation of LRRK2 and LRRK1 expression. BMC Neurosci. 2007;8:102
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory