Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Htr5atm1Rhn
Name:	5-hydroxytryptamine (serotonin) receptor 5A; targeted mutation 1, Rene Hen
MGI ID:	MGI:3513844
Synonyms:	5A-KO
Gene:	Htr5a  Location: Chr5:28047147-28060086 bp, + strand  Genetic Position: Chr5, 13.24 cM, cytoband A3-B
Alliance:	Htr5atm1Rhn page

Germline Transmission:	Earliest citation of germline transmission: J:54098
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace 23% of the coding sequence, including the first and second transmembrane domains, with a neomycin resistance gene. A lack of transcript as shown by Northern blot of brain tissues confirmed successful targeting. (J:54098)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr5a Mutation:	19 strains or lines available

Original:	J:54098 Grailhe R, et al., Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron. 1999 Mar;22(3):581-91
All:	2 reference(s)